What's more, those reductions held even after researchers accounted for other things known to increase a person's risk for liver cancer such as age, obesity, smoking, drinking, sex and diabetes.
However, the study was only designed to show association, not to prove a cause-and-effect relationship. There may be something else common to coffee drinkers that also reduces cancer risk.
Still, it's not the first study to uncover such a link.
A review published last year in the journal Clinical Gastroenterology and Hepatology, which combined the results of 16 different studies involving more than 3,200 patients, concluded that drinking more than three cups of coffee a day might cut the risk of liver cancer by as much as 50 percent.
One expert praised the most recent research.
"This is a really well-done study," said Susan Gapstur, vice president of epidemiology for the American Cancer Society. "It adds to the growing body of evidence that coffee might be associated with a lower risk for a number of cancers."
Beyond liver cancer, studies have suggested that coffee may be tied to reduced risk for head and neck cancers, colorectal cancers, prostate cancer, and bladder, endometrial, esophageal and pancreatic cancers.
What researchers don't yet understand is how coffee may ward off cancer.
"That's what everybody wants to know," said study author V. Wendy Setiawan, an assistant professor in the department of preventive medicine at the USC Norris Comprehensive Cancer Center in Los Angeles.
Setiawan says coffee has close to 100 active compounds including antioxidants, polyphenols and caffeine. It's also known to affect liver enzymes.
"At this time, I don't think anybody has any idea what compound is protective," she said.
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