Gano Life Is Great For The Immune System

Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004 Nov;25(11):1387-95. Ganoderma lucidum ( reishi ) is a medicinal fungus with a variety of biological activities. Reishi has long been used as a folk remedy for promotion of health and longevity in China and other oriental countries. The most attractive character of this kind of medicinal fungus is its effect on the immune system and anti-tumor activities. Large numbers of studies have shown that reishi modulates many components of the immune system such as the antigen-presenting cells, NK cells, T and B lymphocytes. The water extract and the polysaccharides fraction of reishi exhibited significant antitumor effect in several tumor-bearing animals mainly through its immune system enhancing activity. Recent studies also showed that the alcohol extract or the triterpene fraction of reishi possessed anti-tumor effect, which seemed to be related to the cytotoxic activity against tumor cells directly. Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of reishi. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol Sin. 2004 Jun;25(6):833-8. AIM: To investigate the antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide (Reishi). CONCLUSION: GLPP has antitumor and anti-angiogenic activity. The anti-angiogenesis of reishi may be a new mechanism underlying its anti-tumor effects. Ganoderma lucidum (Reishi) inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int J Oncol. 2004 May;24(5):1093-9. Ganoderma lucidum (Reishi), an oriental medical mushroom, has been widely used in Asian countries for centuries to prevent or treat different diseases, including cancer. However, the mechanism(s) responsible for the effects of reishi on cancer cells remain to be elucidated. Our data demonstrate that reishi inhibits cell proliferation in a dose- and time-dependent manner by the down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression. Furthermore, reishi induced apoptosis of PC-3 cells with a slight decrease in the expression of NF-kappaBregulated Bcl-2 and Bcl-xl. Reishi exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer. Hypoglycemic effect of Ganoderma lucidum (reishi) polysaccharides. Acta Pharmacol Sin. 2004 Feb;25(2):191-5. AIM: To investigate the hypoglycemic effect of reishi polysaccharides in the normal fasted mice and its possible mechanism. Normal fasted mice were given a single dose of reishi 25, 50, and 100 mg/kg by i.p. and the serum glucose was measured at 0, 3, and 6 h after administration. Reishi 100 mg/kg were also given by i.p. and the serum glucose and insulin levels were measured at 0 min, 30 min, 1 h, 3 h, 6 h, and 12 h. Pancreatic islets were isolated and incubated with glucose and different concentration of reishi, the insulin content of islets and insulin release were examined. Verapamil and egtazic acid were used to testify whether the insulinreleasing effect of reishi was mediated by its ability to raise the Ca2+ influx. Reishi dose-dependently lowered the serum glucose levels at 3 h and 6 h after administration. Reishi 100 mg/kg raised the circulating insulin levels at 1 h after administration. In vitro, reishi had no effect on islets insulin content, but it stimulated the insulin release after incubation with glucose 5.6 mmol/L. Confocal microscope showed that reishi 100 mg/L had the capacity to raise the [Ca2+]i. The insulin-releasing effect of reishi was inhibited by verapamil/egtazic acid. Reishi possesses the hypoglycemic effect on normal mice; one mechanism is through its insulin-releasing activity due to a facilitation of Ca2+ inflow to the pancreatic beta cells. Please contact me for more information about Ganoderma at ganoforlifeusa@gmail.com.